A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations

23 November 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A modular flow platform for the synthesis of natural products and their analogs was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from conventional liquid- to gas-driven flow, reagent and solvent waste is minimized which translates into an advantageous sustainability and economy profile. To enable inert conditions, practical “Schlenk-in-flow” techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.


flow chemistry
C−H activation
late-stage modification
natural products
total synthesis

Supplementary materials

SI Heretsch


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