Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

Timothy Kench; Peter A. Summers; Marina K. Kuimova; James Lewis; Ramon Vilar

doi:10.26434/chemrxiv.13249643.v1

Biological and Medicinal Chemistry

Search within Biological and Medicinal Chemistry

Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

18 November 2020, Version 1

Working Paper

Show author details

This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

Keywords

Supplementary materials

Title

Description

Actions

Title

Rotaxane-G4-SupplementaryInformation

Description

Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here .

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.