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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

18 November 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

Keywords

RotaxaneInterlocked
quadruplexes
DNA binders
Optical probe
platinum salphen
photoactivation

Supplementary materials

Title
Description
Actions
Title
Rotaxane-G4-SupplementaryInformation
Description
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Now Published

Rotaxanes as Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule** [opens in a new tab]
Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis, Ramon Vilar journal article
Angewandte Chemie International Edition , Volume 60, Issue 19
Online publication date: Mar 30, 2021

Version History

Nov 18, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13249643.v1
D O I: 10.26434/chemrxiv.13249643.v1 [opens in a new tab]

Author’s competing interest statement

No conflict of interest

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