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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

Working Paper

Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

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Supplementary material

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Rotaxane-G4-SupplementaryInformation

Now Published

Rotaxanes as Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule**

Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis, Ramon Vilar journal article

Angewandte Chemie International Edition , Volume 60, Issue 19

Online publication date: Mar 30, 2021

Version History

Nov 18, 2020 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv.13249643.v1

Author’s competing interest statement

No conflict of interest

Keywords

RotaxaneInterlocked

quadruplexes

DNA binders

Optical probe

platinum salphen

photoactivation

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.