Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

Timothy Kench; Peter A. Summers; Marina K. Kuimova; James Lewis; Ramon Vilar

doi:10.26434/chemrxiv.13249643.v1

Biological and Medicinal Chemistry

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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

18 November 2020, Version 1

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Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

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Rotaxane-G4-SupplementaryInformation

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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule**

Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis, Ramon Vilar journal article

Angewandte Chemie International Edition , Volume 60, Issue 19

Online publication date: Mar 30, 2021

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Nov 18, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.13249643.v1

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No conflict of interest

Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

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