Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

18 November 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

Keywords

RotaxaneInterlocked
quadruplexes
DNA binders
Optical probe
platinum salphen
photoactivation

Supplementary materials

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Description
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Title
Rotaxane-G4-SupplementaryInformation
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