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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

Abstract

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

Content

Thumbnail image of Rotaxane-G4-Manuscript-PDF.pdf

Supplementary material

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Rotaxane-G4-SupplementaryInformation

Now Published

Rotaxanes as Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule**

Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis, Ramon Vilar

Angewandte Chemie International Edition, Volume 60, Issue 19

Published Mar 30, 2021

Version History

Nov 18, 2020 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv.13249643.v1

Author’s competing interest statement

No conflict of interest

Keywords

RotaxaneInterlocked

quadruplexes

DNA binders

Optical probe

platinum salphen

photoactivation

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.

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