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Dual Color Imaging from a Single BF2-Azadipyrromethene Fluorophore Demonstrated in vivo for Lymph Node Identification

Abstract

Dual color fluorescence imaging has been achieved in the highly complex biomedical scenario of lymph node mapping. Emissions at 700 and 800 nm can be achieved from a single fluorophore by establishing molecular and aggregate forms. Fluorophore was compatible with clinical systems for fluorescence guided surgery and no toxicity was observed in high dosage testing.

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Dual Color Imaging from a Single BF2-Azadipyrromethene Fluorophore Demonstrated in vivo for Lymph Node Identification [opens in a new tab]
Niamh Curtin, Dan Wu, Ronan Cahill, Anwesha Sarkar, Pól Mac Aonghusa, Sergiy Zhuk, Manuel Barberio, Mahdi Al-Taher, Jacques Marescaux, Michele Diana, Donal F. O'Shea journal article
International Journal of Medical Sciences , Volume 18, Issue 7
Print publication date: 2021

Version History

Nov 09, 2020 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org [opens in a new tab]

DOI

10.26434/chemrxiv.13203641.v1
D O I: 10.26434/chemrxiv.13203641.v1 [opens in a new tab]

Funding

This work was supported with funding support from the Irish Government Department of Business, Enterprise and Innovation’s Disruptive Technology Innovation Fund. DOS gratefully acknowledges Science Foundation Ireland grant number 17/TIDA/4936 and AMBER 12/RC/2278 P2 for financial support. MD acknowledges additional funding provided by the ARC Foundation (https://www.fondation-arc.org/), via the ELIOS grant.

Author’s competing interest statement

DFOS has a financial interest in patents filed and granted relating to NIR-fluorophores and processes for visual determination of tissue biology. RC is named on a patent filed in relation to processes for visual determination of tissue biology and receives speaker fees from Stryker Corp, consultancy fees from Distal Motion and holds research funding from Intuitive Corp and with IBM Corp and Deciphex. PMA, SZ are full-time employees of IBM Research, a division of IBM Corporation. IBM Corporation provides technical products and services world-wide to government, healthcare and life-sciences companies. PMA, SZ hold and have filed patents concerning technologies related to the subject matter of this paper. MD is member of the Advisory Board of Diagnostic Green and is the recipient of the ELIOS grant from the ARC Foundation. JM is the President of the IRCAD Institute, which is partly funded by KARL STORZ and Medtronic.

Keywords

NIR-AZA fluorophore;
dual fluorescence
J aggregate
fluorescence-guided surgery
lymph node mapping

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.