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Biological and Medicinal Chemistry

Collaborative Virtual Screening to Elaborate an Imidazo[1,2-A]pyridine Hit Series for Visceral Leishmaniasis

Abstract

An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. Parasitology and early ADME data is presented.

Version notes

v1 - submitted for peer review

Content

Thumbnail image of Akao et al Oct 2020 preprint format.pdf

Supplementary material

Thumbnail image of SI 1 intro and assays final.pdf
SI 1 intro and assays final
Thumbnail image of SI 2 - Table of compounds final.pdf
SI 2 - Table of compounds final
Thumbnail image of SI 3 - experimental final.pdf
SI 3 - experimental final
Thumbnail image of SI 4 - Analytical data final.pdf
SI 4 - Analytical data final

Version History

Nov 04, 2020 Version 1

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License

CC logo BY logo NC logo ND logo
The content is available under CC BY NC ND 4.0 License CreativeCommons.org [opens in a new tab]

DOI

10.26434/chemrxiv.13134785.v1
D O I: 10.26434/chemrxiv.13134785.v1 [opens in a new tab]

Funding

GHIT

Author’s competing interest statement

There are no conflicts of interest to declare

Keywords

Infectious Disease
Medicinal Chemistry
In silico
Leishmania donovani
leishmaniasis treatment
Collaboration Networks Community structures

Publication

This content is an early or alternative research output and has not been peer-reviewed at the time of posting.