Guest Encapsulation Within Surface-Adsorbed Self-Assembled Cages

15 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Coordination cages encapsulate a wide variety of guests in the solution state. This ability renders them useful for applications such as catalysis and the sequestration of precious materials. Here we report a simple and general method for the immobilisation of coordination cages on alumina. Cage loadings were quantified via adsorption isotherms and guest displacement assays demonstrated that the adsorbed cages retained the ability to encapsulate and separate guest and non-guest molecules. Finally, we used a system of two cages adsorbed on to different regions of alumina to stabilise and separate a pair of Diels-Alder reagents. The addition of a single competitive guest resulted in the controlled release of the reagents, thus triggering their reaction. We envisage this method of coordination cage immobilisation on solid phases to be applicable to the extensive library of reported cages, enabling new applications based upon selective solid-phase molecular encapsulation.


Coordination Cages
Host-Guest Chemistry

Supplementary materials

Hugh Ryan Adsorption Supplementary Information


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.