Polymers of a Transition-State Sialyl Cation Strongly Inhibit Bacterial Sialidases.

29 September 2020, Version 1

Abstract

Conjugation of the transitionstate-cation analogue DANA to polymeric scaffolds led to highly potent inhibitors of bacterial sialidases. Each clustered DANA on the polymers saw its inhibitory potency for S. pneumoniae or B. thetaiotaomicron sialidases improved by more than four orders of magnitude. This extends the multivalent concept to this important class of enzymes.

Keywords

enzymes
sialidase inhibitor
multivalency

Supplementary materials

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