A Bright Deep-Red AIEgen with Locked Noncoplanar Conformation for Lipid Droplet-Specific Imaging

19 October 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


In the field of fluorescent materials, bright deep-red/near-infrared (DR/NIR) luminogens are always in demand whose rationally and accurately design yet are challenging. Current design strategy of DR/NIR emitters mainly depends on the construction of large p-conjugation and strong donor-acceptor system, which commonly suffers the quenching factors from p-p stacking and twisted intramolecular charge transfer (TICT) effect. In this work, we employed the non-covalent interactions and constructed a luminogen with rigid and twisted conformation, which not only red-shifts the emission wavelength of the luminogen to DR/NIR region but also effectively suppresses the non-radiative decay by p-p stacking and TICT. Moreover, the rational molecular design endows the new luminogen with two-photo absorption capability and superior selectivity towards lipid droplets in different levels including living cells, tissues, and live fish embryo. This work thus presents an elegant, facile and efficient strategy for generating functional DR/NIR emitters.


Bright deep-red emission
Conformation lock
Lipid droplet imaging

Supplementary materials

Conformation lock ESI-1017


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.