Working Paper
Authors
- Jia-Wang Wang ,
- Yan Li ,
- Wan Nie ,
- Zhe Chang ,
- Zi-An Yu ,
- Yi-Fan Zhao ,
- Xi Lu
University of Science and Technology of China ,
- Yao Fu
Abstract
Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamine to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles.
Content

Supplementary material

reductive alkylation of enamines-Supporting Information-20200919