Catalysis

Catalytic Asymmetric Reductive Alkylation of Enamines to Chiral Aliphatic Amines

Authors

Abstract

Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamine to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles.

Content

Thumbnail image of reductive alkylation of enamines-Manuscript-20201013.pdf

Supplementary material

Thumbnail image of reductive alkylation of enamines-Supporting Information-20200919.pdf
reductive alkylation of enamines-Supporting Information-20200919