Catalytic Asymmetric Reductive Alkylation of Enamines to Chiral Aliphatic Amines



Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamine to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles.


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Supplementary material

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reductive alkylation of enamines-Supporting Information-20200919