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Virtual Screening of Leishmanial Pyridoxal Kinase Enzyme Inhibitors by Repurposed Anti-Trypanosomal Libraries Reveals Two Core Scaffolds

13 October 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Leishmania is an intracellular protozoal infection, and it is classified as a neglected disease by the World Health Organization (WHO). Annually more than 2 million newly diagnosed cases were treated with highly toxic drugs. Leishmanial pyridoxal kinase enzyme (LPDxK) is an essential and druggable target. DNDI1103666 is the most promising lead as a potential inhibitor for LPDxK

Keywords

Neglected diseases
Leishmania
virtual screening
LPDxK
Leishmanial pyridoxal kinase inhibitors
repurposing

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Version History

Oct 13, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13077395.v1
D O I: 10.26434/chemrxiv.13077395.v1 [opens in a new tab]

Author’s competing interest statement

no conflict of interest

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