Working Paper
Authors
- Alexander Steiner ,
- Desiree Znidar ,
- Sándor B. Ötvös ,
- David R. Snead ,
- Doris Dallinger
University of Graz ,
- C. Oliver Kappe
Abstract
A simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17% to 61%, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.
Content

Supplementary material

EIDD-2801 SI ChemRxiv