Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS Analysis

07 October 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study describes the development of a novel assay for SARS-CoV-2 identification using LC-MS/MS analysis. A multi-step procedure for the rational down-selection of a set of markers has leaded to the discovery of six SARS-CoV-2 specific and sensitive markers, enabling the reliable identification of the virus. A rapid and simple assay was developed, successfully applied to clinical nasopharyngeal samples. The assay may potentially serve as a complementary approach for SARS-CoV-2 identification.

Keywords

SARS-CoV-2
identification method
LC-MS/MS
Spike
Nucleoprotein
marker

Supplementary materials

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