A New Perspective for Litholysis? Influence of Amines on the Solubility of Kindney Stones in Vitro

06 October 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


It was shown that amines increase the equilibrium solubility of uric acid kidney
stones substantially and stabilize the process of litholysis in due course. However, these amines compete with ammonium in salt formation. Imidazole and triethanolamine are stabilize of uric acid solubility when [NH 4+ ] < 20 mM, and piperazine promotes the dissolution of uric acid if [NH 4+ ] > 46 mM. In salt solutions simulating complete cationic composition of
human urine, solubility of uric acid is practically the same for the systems with imidazole and piperazine and it is some lower for triethanolamine containing system


kidney stone
equilibrium solubility


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.