The First Glycosides with Pyrazolo[3,4-C]isoquinoline Aglycone Moiety. Synthesis and NMR Structure Investigation

we describe the methods of obtaining N- and O-glycosides with the pyrazolo[3,4-c]isoquinoline as aglycone moiety. O-glycosides are obtained in good yields under phase transfer catalysis. Mercury (II) bromide is used for glycosylation of nitrogen atom at pyrazole ring. NMR study of the structure has shown high stability of the glycoside residue proton signals. Studies of the biological activity of the compounds is underway and will be presented in due course.