Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters

28 August 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This manuscript outlines a high-throughput 96-well plate assay to measure the vesicular uptake of the false fluorescent neurotransmitter FFN206 by the vesicular monoamine transporter 2 (VMAT2) in near real-time and following pharmacological and environmental toxicant exposure in HEK293 cells.

Keywords

Dopamine
Parkinson's disease
VMAT2
FFN
FFN206
monoamine
vesicle

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