Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters

Carlie A. Hoffman; Meghan Bucher; Joshua M. Bradner; Lauren Jonas; Kenny Igarza; Gary W. Miller

doi:10.26434/chemrxiv.12880070.v1

Biological and Medicinal Chemistry

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Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters

28 August 2020, Version 1

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This manuscript outlines a high-throughput 96-well plate assay to measure the vesicular uptake of the false fluorescent neurotransmitter FFN206 by the vesicular monoamine transporter 2 (VMAT2) in near real-time and following pharmacological and environmental toxicant exposure in HEK293 cells.

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Aug 28, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12880070.v1

Author’s competing interest statement

The authors declare no conflicts of interest.

Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters

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Abstract

Keywords

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DOI

Author’s competing interest statement

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