Biological and Medicinal Chemistry

Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters

Abstract

This manuscript outlines a high-throughput 96-well plate assay to measure the vesicular uptake of the false fluorescent neurotransmitter FFN206 by the vesicular monoamine transporter 2 (VMAT2) in near real-time and following pharmacological and environmental toxicant exposure in HEK293 cells.

Content

Thumbnail image of Hoffman et al. Assessing vesicular monoamine transport and toxicity using fluorescent false neurotransmitters.pdf