Analytical Chemistry

Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry


When electrosprayed from native solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial structure in solution. Here we show the limits of using force field molecular dynamics to interpret the gas-phase structures of nucleic acid complexes in the gas phase, and we suggest that higher-level calculation levels should be used in the future.

Version notes

July 3, 2020: revised version


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Supplementary material

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200703 KC-in-gas revised2 SI