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Route Efficiency Assessment and Review of the Synthesis of β-Nucleosides via N-Glycosylation of Nucleobases

07 August 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Instead of focusing on maximizing glycosylation yield, future syntheses of nucleosides via N-glycosylation should aim to use shorter routes, fewer protecting groups and less chromatography to achieve more efficient and sustainable processes, as this E-factor analysis reveals.

Keywords

Nucleoside
E-factor
yield
solvent
chromatography
glycosylation
sugar

Supplementary materials

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Description
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Supporting Info Kaspar 2020 N-Glycosylation
Description
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SI Kaspar 2020 N-Glycosylation
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Now Published

Route efficiency assessment and review of the synthesis of β-nucleosides via N-glycosylation of nucleobases [opens in a new tab]
Felix Kaspar, M. Rhia L. Stone, Peter Neubauer, Anke Kurreck journal article
Green Chemistry , Volume 23, Issue 1
Online publication date: 2021

Version History

Aug 07, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12753413.v1
D O I: 10.26434/chemrxiv.12753413.v1 [opens in a new tab]

Author’s competing interest statement

A. K. is CEO of the biotech company BioNukleo GmbH. F. K. is a scientist at BioNukleo GmbH and P. N. is a member of the advisory board. These affiliations constitute no conflict of interest with the results presented and discussed in this report.

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