Impact of Conformations and Size on the Antileishmanial Activity of New Quinazoline Derivatives

03 August 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


There is an urgency of finding molecules available to treat Leishmaniasis, which is one of the significant issues of health in undeveloped countries. For that reason is needed to explore molecular diversity to find novel scaffolds. Fluorinated and adamantane derivatives exhibit a formidable starting point. They are proved to improve the antileishmanial activity when attached to molecules already active as we have shown in this paper. Particularly fluorinated methoxy and ethoxy derivatives can increase its volume depending on the number of fluorine, a unique behaviour that can be exploited for molecular drug design purposes.


Leishmania mexicana parasites
drug design challenges
Computer Aided Drug Design
DHFR enzymes
fluorine atoms exhibit
fluorine bridges

Supplementary materials



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