Concise Chemoenzymatic Total Synthesis of GE81112 B1

Christian Zwick; Max Sosa; Hans Renata

doi:10.26434/chemrxiv.9684554.v1

Catalysis

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Concise Chemoenzymatic Total Synthesis of GE81112 B1

20 August 2019, Version 1

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Abstract

We report a chemoenzymatic total synthesis of GE81112 B1 that employs biocatalytic hydroxylation to prepare two of the key monomers of the target natural product. By pairing this strategy with traditional organic chemistry, we were able to synthesize GE81112 B1 in 11 steps.

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GE81112 SI combined FINAL

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