Catalysis

Concise Chemoenzymatic Total Synthesis of GE81112 B1

Authors

Abstract

We report a chemoenzymatic total synthesis of GE81112 B1 that employs biocatalytic hydroxylation to prepare two of the key monomers of the target natural product. By pairing this strategy with traditional organic chemistry, we were able to synthesize GE81112 B1 in 11 steps.

Content

Thumbnail image of GE81112 Manuscript Chemrxiv.pdf

Supplementary material

Thumbnail image of GE81112 SI combined FINAL.pdf
GE81112 SI combined FINAL