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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

20 July 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.

Keywords

Kir channels
Aedes aegypti
Zika virus
Dengue virus
vector-borne diseases
larvicides

Supplementary materials

Title
Description
Actions
Title
AeKir Heterocyclic Supporting Information V6 Fin
Description
Actions

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Now Published

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 ( Ae Kir) Channel and Larvicides [opens in a new tab]
Christopher D. Aretz, Sujay V. Kharade, Keagan Chronister, Renata Rusconi Trigueros, Erick J. Martinez Rodriguez, Peter M. Piermarini, Jerod S. Denton, Corey R. Hopkins journal article
ChemMedChem , Volume 16, Issue 2
Online publication date: Oct 28, 2020

Version History

Jul 20, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12662690.v1
D O I: 10.26434/chemrxiv.12662690.v1 [opens in a new tab]

Funding

R21 AI128418

Author’s competing interest statement

The authors declare no Conflict of Interest.

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