Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

20 July 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.

Keywords

Kir channels
Aedes aegypti
Zika virus
Dengue virus
vector-borne diseases
larvicides

Supplementary materials

Title
Description
Actions
Title
AeKir Heterocyclic Supporting Information V6 Fin
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 ( Ae Kir) Channel and Larvicides [opens in a new tab]
Christopher D. Aretz, Sujay V. Kharade, Keagan Chronister, Renata Rusconi Trigueros, Erick J. Martinez Rodriguez, Peter M. Piermarini, Jerod S. Denton, Corey R. Hopkins journal article
ChemMedChem , Volume 16, Issue 2
Online publication date: Oct 28, 2020

Version History

Jul 20, 2020 Version 1

Metrics

1,965
286
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12662690.v1
D O I: 10.26434/chemrxiv.12662690.v1 [opens in a new tab]

Funding

R21 AI128418

Author’s competing interest statement

The authors declare no Conflict of Interest.

Share