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Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores

13 July 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophores

Late stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.

Keywords

Macrocycles
Phage display
1,3-diketone
Hydrazine

Supplementary materials

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Now Published

Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores [opens in a new tab]
Arunika I. Ekanayake, Lena Sobze, Payam Kelich, Jihea Youk, Nicholas J. Bennett, Raja Mukherjee, Atul Bhardwaj, Frank Wuest, Lela Vukovic, Ratmir Derda journal article
Journal of the American Chemical Society , Volume 143, Issue 14
Online publication date: Mar 30, 2021

Version History

Jul 13, 2020 Version 1

Version Notes

This is the first version.

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12644225.v1
D O I: 10.26434/chemrxiv.12644225.v1 [opens in a new tab]

Funding

RGPIN-2016-402511

Author’s competing interest statement

R.D. is the C.E.O. and a shareholder of 48Hour Discovery Inc., the company that licensed the patent application describing silent encoding and chemical modification technologies.

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