Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores

13 July 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophores

Late stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.

Keywords

Macrocycles
Phage display
1,3-diketone
Hydrazine

Supplementary materials

Title
Description
Actions
Title
Data
Description
Actions
Title
Derda SI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores [opens in a new tab]
Arunika I. Ekanayake, Lena Sobze, Payam Kelich, Jihea Youk, Nicholas J. Bennett, Raja Mukherjee, Atul Bhardwaj, Frank Wuest, Lela Vukovic, Ratmir Derda journal article
Journal of the American Chemical Society , Volume 143, Issue 14
Online publication date: Mar 30, 2021

Version History

Jul 13, 2020 Version 1

Version Notes

This is the first version.

Metrics

9,365
1,498
2
Views
Downloads

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12644225.v1
D O I: 10.26434/chemrxiv.12644225.v1 [opens in a new tab]

Funding

RGPIN-2016-402511

Author’s competing interest statement

R.D. is the C.E.O. and a shareholder of 48Hour Discovery Inc., the company that licensed the patent application describing silent encoding and chemical modification technologies.

Share