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A Novel Enzyme-Triggered Domino Reaction Producing Fluorescent Quinoxalin-2(1H)-One-Based Heterocycles

07 July 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A simple and effective biocompatible domino reaction triggered by a model protease and leading to formation of strongly fluorescent quinoxalin-2(1H)-one N-heterocycles is described. Some positive attributes including versatility and ability to provide outstanding fluorescence "OFF-ON" responses were revealed by this work. They open the way for practical applications of this novel type of "covalent-assembly" based fluorescent probes in the fields of sensing and bioimaging.

Keywords

biocompatible reactions
covalent assembly
fluorescent probe
protease
Quinoxalinone

Supplementary materials

Title
Description
Actions
Title
Publication-Quinox-ChemRxiv-SI
Description
Actions

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Version History

Jul 07, 2020 Version 1

Version Notes

Version 1 06.07.2020

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License

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12613862.v1
D O I: 10.26434/chemrxiv.12613862.v1 [opens in a new tab]

Funding

Agence Nationale de la Recherche
ANR-18-CE39-0014
Butyrylcholinesterase-based fluorescent and/or colorimetric detection of organophosphorus nerve agents – DetectOP_BChE
https://app.dimensions.ai/details/grant/grant.8639576 [opens in a new tab]
Agence Nationale de la Recherche
ANR-18-CE07-0045
A luminogenic real-time detection system for monitoring enzymatic manufacturing of oligonucleotides – LuminoManufacOligo
https://app.dimensions.ai/details/grant/grant.8638501 [opens in a new tab]
PO FEDER-FSE Bourgogne 2014/2020

Author’s competing interest statement

No conflict of interest

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