Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

Tao Xiong; Wei Guan; Qian Zhang; Ge Zhang; Yujie Liang; Tao Qin; Shuyu Liu

doi:10.26434/chemrxiv.12606554.v1

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Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

06 July 2020, Version 1

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Abstract

Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.

Keywords

asymmetric catalysis

umpolung hydroamination

chiral β-amino acid and its derivatives

copper catalysis toolbox

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2020.7.2-2 SI

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Copper-Catalyzed Asymmetric Hydroamination: A Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

Ge Zhang, Yujie Liang, Tao Qin, Tao Xiong, Shuyu Liu, Wei Guan, Qian Zhang journal article

CCS Chemistry , Volume 3, Issue 7

Print publication date: Jul, 2021

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Jul 06, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12606554.v1

Author’s competing interest statement

The authors declare no competing financial interest.

Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

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