Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

06 July 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.


asymmetric catalysis
umpolung hydroamination
chiral β-amino acid and its derivatives
copper catalysis toolbox

Supplementary materials

2020.7.2-2 SI


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