Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives


Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.


Supplementary material

2020.7.2-2 SI