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Differences in the Performance of Allyl Based Palladium Precatalysts for Suzuki-Miyaura Reactions

29 June 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We evaluate the activity of different allyl-based precatalysts in Suzuki-Miyaura reactions as the ancillary ligand (NHC or phosphine), reaction conditions, and substrates are varied. In some cases, we connect relative activity to both the mechanism of activation and the prevalence of the formation of inactive palladium(I) dimers.

Keywords

Suzuki reactions
Precatalyst
Palladium
Activation

Supplementary materials

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Version History

Jun 29, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12573608.v1
D O I: 10.26434/chemrxiv.12573608.v1 [opens in a new tab]

Funding

NIHGMS R01GM120162

Author’s competing interest statement

This work was primarily funded by Umicore, who own the rights to all of the allyl-based precatalysts studied in this work. Additionally, NH is an inventor on patents relating to the Yale precatalyst.

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