Abstract
A family of three picolinate pyclen based ligands,
previously investigated for the complexation of Y3+ and some
lanthanide ions (Gd3+, Eu3+), was studied with 161Tb
and 177Lu in view of potential radiotherapeutic applications. The
set of six Tb3+ and Lu3+ complexes was synthesized and
fully characterized. The coordination properties in the solid state and in
solution were thoroughly studied. Potentiometric titrations, corroborated by
DFT calculations, showed the very high stability constants of the Tb3+
and Lu3+ complexes, which are associated to remarkable kinetic inertness.
A complete radiolabeling study performed with both 161Tb and 177Lu
radionuclides, including experiments with regard to the stability with and
without scavengers and kinetic inertness using challenging agents, proved that
the ligands could reasonably compete with the DOTA analogue. To conclude, the
potential of using the same ligand for both radiotherapy and optical imaging
was highlighted for the first time.
Supplementary materials
Title
Nizou Favaretto MainManu chemRxiv
Description
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