Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-Amides to N-Fused Spirolactams

29 June 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Using the spiro-cyclization of amides as a model reaction we have demonstrated that aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation. This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.

Keywords

hypervalent iodine
dual organocatalysis
aerobic photoredox reaction
pyrylium

Supplementary materials

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SupportingDualAerobic
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