Inorganic Chemistry

Zinc Protoporphyrin–trimethylamine-N-Oxide Complex Involves Cholesterol Oxidation Causing Atherosclerosis

Sabyasachi Sarkar Ramakrishna Mission Vidyamandira, Belurmath-711202 West Bengal

Abstract

Trimethylamine-N-oxide (TMAO) has recently been correlated as biomarker for atherosclerosis. In a model study, we show that the free TMAO when bonded with zincprotoporphyrin IX, [ZnPP], in blood plasma as [TMAOZnPP] is transported to the lipid site is the reacting species to oxidize cholesterol causing atherosclerosis

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Supplementary material

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