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Zinc Protoporphyrin–trimethylamine-N-Oxide Complex Involves Cholesterol Oxidation Causing Atherosclerosis

26 June 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Trimethylamine-N-oxide (TMAO) has recently been correlated as biomarker for atherosclerosis. In a model study, we show that the free TMAO when bonded with zincprotoporphyrin IX, [ZnPP], in blood plasma as [TMAOZnPP] is transported to the lipid site is the reacting species to oxidize cholesterol causing atherosclerosis

Keywords

atherosclerosis
Trimethylamine-N-oxide (TMAO)
zinc protoporphyrin
cholesterol oxidation
phase transfer
plaque

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Now Published

Zinc protoporphyrin–trimethylamine-N-oxide complex involves cholesterol oxidation causing atherosclerosis [opens in a new tab]
Navendu Paul, Rudra Sarkar, Sabyasachi Sarkar journal article
JBIC Journal of Biological Inorganic Chemistry , Volume 26, Issue 2-3
Online publication date: Mar 13, 2021

Version History

Jun 26, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12548006.v1
D O I: 10.26434/chemrxiv.12548006.v1 [opens in a new tab]

Funding

SERB-DST (EMR/2015/001328), New. Delhi

Author’s competing interest statement

There are no conflicts to declare

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