Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

wei zhu; Miaomiao Kang; qian wu; Zhijun Zhang; yi wu; Chunbin Li; Kai LI; Lei Wang; Dong Wang; Ben Zhong Tang

doi:10.26434/chemrxiv.12464120.v1

Materials Science

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Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

16 June 2020, Version 1

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Abstract

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

Keywords

aggregation-induced emission

NIR-II fluorescence imaging

photodynamic therapy

photothermal therapy

anticancer

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