Exosome-Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission

04 June 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The fusion and fission behaviors of exosomes are essential for the cell-to-cell communication. Developing exosome-mimetic vesicles with such behaviors is of vital importance, but still remains a big challenge. Herein, we present an artificial supramolecular vesicle that exhibits redox-modulated reversible fusion-fission functions. These vesicles tend to fuse together and form large-sized vesicles upon oxidation, while undergo a fission process and return to smallsized vesicles through reduction. Noteworthy, the aggregationinduced emission (AIE) characteristics of the supramolecular building blocks enable the molecular configuration during vesicular transformation to be monitored by fluorescence technology. Moreover, the presented vesicles are excellent nanocarrier candidates to transfer siRNA into cancer cells.


Supramolecular vesicles
Aggregation-induced emission
Fission and fusion

Supplementary materials



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