Organic Chemistry

Assessment of the Organocatalytic Activity of Chiral L-Proline-Based Deep Eutectic Solvents Based on their Structural Features

Abstract

In this paper L-Proline-based Chiral Deep Eutectic Solvents (CDESs) were prepared and used as green and organocatalytic reaction media in a probe asymmetric Michael addition; in this reaction the L-Proline acts as solvent component as well as chiral organocatalyst. The results were analysed with NMR studies taking in account the availability of the L-Proline considering the strength of the association of it with the counterpart of the liquids. With DFT studies, the geometry and energy of the adducts are showed and a qualitative rationale to the reaction stereoisomers distribution is given.

Content

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Supplementary material

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Supplementary Material ASSESSMENT OF THE ORGANOCATALYTIC ACTIVITY OF CHIRAL L-PROLINE-BASED DEEP EUTECTIC SOLVENTS BASED ON THEIR STRUCTURAL FEATURES