Abstract
A mild and practical method has been achieved that
allows for the direct C–H trifluoromethylation, perfuoroalkylation and
chlorodifluoromethylation of (hetero)arenes using inexpensive and abundant
trifluoroacetic acid and the corresponding carboxylic acids. A diverse array of
arenes and heteroarenes were successfully transformed into valuable
fluoroalkylated compounds. The combination of photoredox catalysis and a diaryl
sulfoxide provides a platform for the facile generation of fluoroalkyl radicals
from the corresponding fluoroalkyl carboxylic acids under mild conditions.
Supplementary materials
Title
TOC Abstract
Description
Actions