Biological and Medicinal Chemistry

Designing of Cytotoxic and Helper T Cell Epitope Map Provides Insights into the Highly Contagious Nature of the Pandemic Novel Coronavirus SARS-CoV2

Dr. Seema Mishra University of Hyderabad

Abstract

This study provides key insights into the contagious nature of SARS-CoV2 through analyses of T cell epitopes designed from SARS-CoV2 proteome. All top-scoring cytotoxic T cell epitopes from ORF1ab and helper T cell epitopes identified from all proteins were utilized to provide crucial insights into its pathogenesis. These T cell epitopes can be used as prophylactic or therapeutic multi-subunit vaccine or as diagnostic tools.

Content

Thumbnail image of PaperSeema.pdf
download asset PaperSeema.pdf 0.28 MB [opens in a new tab]

Supplementary material

Thumbnail image of muscleEnvelope.txt
download asset muscleEnvelope.txt 0.00 MB [opens in a new tab]
muscleEnvelope
Thumbnail image of muscleMembrane.txt
download asset muscleMembrane.txt 0.00 MB [opens in a new tab]
muscleMembrane
Thumbnail image of muscleNS3.txt
download asset muscleNS3.txt 0.00 MB [opens in a new tab]
muscleNS3
Thumbnail image of muscleNS6.txt
download asset muscleNS6.txt 0.00 MB [opens in a new tab]
muscleNS6
Thumbnail image of muscleNucleocapsid.txt
download asset muscleNucleocapsid.txt 0.01 MB [opens in a new tab]
muscleNucleocapsid
Thumbnail image of muscleORF1ab.txt
download asset muscleORF1ab.txt 0.07 MB [opens in a new tab]
muscleORF1ab
Thumbnail image of muscleORF7a.txt
download asset muscleORF7a.txt 0.00 MB [opens in a new tab]
muscleORF7a
Thumbnail image of muscleORF8.txt
download asset muscleORF8.txt 0.00 MB [opens in a new tab]
muscleORF8
Thumbnail image of muscleSpike.txt
download asset muscleSpike.txt 0.02 MB [opens in a new tab]
muscleSpike
Thumbnail image of S4_Supplementary material_PickPocket.xlw
download asset S4_Supplementary material_PickPocket.xlw 2 MB [opens in a new tab]
S4 Supplementary material PickPocket
Thumbnail image of S5_Supplementary material_NetCTLpan_results.xlw
download asset S5_Supplementary material_NetCTLpan_results.xlw 11 MB [opens in a new tab]
S5 Supplementary material NetCTLpan results
Thumbnail image of S6_Supplementary material_NetMHCIIpan_results.xlw
download asset S6_Supplementary material_NetMHCIIpan_results.xlw 15 MB [opens in a new tab]
S6 Supplementary material NetMHCIIpan results
Thumbnail image of Supplementary Figure S10.doc
download asset Supplementary Figure S10.doc 0.33 MB [opens in a new tab]
Supplementary Figure S10
Thumbnail image of Supplementary table S1.xlw
download asset Supplementary table S1.xlw 0.01 MB [opens in a new tab]
Supplementary table S1
Thumbnail image of Supplementary table S2.xlw
download asset Supplementary table S2.xlw 0.35 MB [opens in a new tab]
Supplementary table S2
Thumbnail image of Supplementary table S3.xlw
download asset Supplementary table S3.xlw 0.19 MB [opens in a new tab]
Supplementary table S3