Arene Dearomatization via a Catalytic N-Centered Radical Cascade Reaction

23 April 2020, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


This photocatalysis methodology leverages N-centered radicals, from easily prepared γ,δ-unsaturated N-arylsulfonyl enamides, to initiate a carboamination/dearomatization cascade reaction that generates stereodefined 1,4-cyclohexadiene-fused sultams. This unique reactivity serves as a general platform for arene dearomatization and the fused heterocyclic products are viewed as valuable building blocks for drug discovery programs.


photoredox catalysis
N-centered radicals
Dearomatization Reactions
proton coupled electron transfer
cascade reaction


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