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Enantiomeric Excess Dependent Splitting of NMR Signal Through Co-Ligand Dynamic Exchange in a Coordination Complex

28 April 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A coordination complex (L·2Zn·3C), where L is a prochiral ligand and C is an exchangeable acetate co-ligand, exhibits symmetrical splitting of 1H-NMR resonances due to L, which is proportional to the enantiomeric excess (ee) of a chiral guest co-ligand, 2-phenoxypropionic acid (PPA). The NMR resonances remain split even in dilute solution due to the high stability of complex with chiral guest.

Keywords

chirality detection
prochirality
NMR
chirality transfer
Coordination chemistry
enantiomeric excess
Titration

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Now Published

Enantiomeric Excess Dependent Splitting of NMR Signal through Dynamic Chiral Inversion and Coligand Exchange in a Coordination Complex [opens in a new tab]
Kazuyoshi Takimoto, Shinsuke Ishihara, Jan Labuta, Václav Březina, Daniel T. Payne, Jonathan P. Hill, Katsuhiko Ariga, Masato Sumita, Shigeki Mori, Hisako Sato journal article
The Journal of Physical Chemistry Letters , Volume 11, Issue 19
Online publication date: Sep 09, 2020

Version History

Apr 28, 2020 Version 1

Version Notes

This is the first version

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12198945.v1
D O I: 10.26434/chemrxiv.12198945.v1 [opens in a new tab]

Funding

JSPS KAKENHI Grant No. JP16H06518 (Coordination Asymmetry), and Grant No. 19K05229

Author’s competing interest statement

There is no conflict of interest.

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