Newly Developed Semi-Synthetic Chloroquine and Hydroxychloroquine-Phytochemical Conjugates as Prospective COVID-19 Drug(s)

27 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Dear Editor,

Kindly find a research article entitled “Newly developed semi-synthetic chloroquine and hydroxychloroquine-phytochemical conjugates as prospective COVID-19 drug(s)”, submitted for consideration for publication. Kindly find the Herein, two series of chloroquine (CQ) and hydroxychloroquine (HCQ) derivatives were chemically conjugated with established small phenolic phytochemicals namely, thymol, vanillin, guaiacol, eugenol, 4-hydroxycoumarin and vanillin analogues by the principles of Williamson ether reaction. The HCQ-vanillin conjugation would be coveted as a potential candidate against human COVID-19.

Thanking you,

With regards,

Rabindra Nath Padhy, PhD, Post-Doc, Member NAMS.

Professor and Head, Central Research Laboratory, IMS & Sum Hospital,

Siksha ‘O’ AnusandhanDeemed to be University,

Bhubaneswar- 751003, Odisha, India.

E-mail: [email protected]


Chloroquine Ligands
Synthesis conditions
Corona virus


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