Organic Chemistry

Synthesis of Tertiary Amines by Direct Brønsted Acid Catalyzed Reductive Amination

Authors

Abstract

Tertiary amines are ubiquitous and valuable compounds in synthetic chemistry, with a wide range of applications in organocatalysis, organometallic complexes, biological processes and pharmaceutical chemistry. One of the most frequently used pathways to synthesize tertiary amines is the reductive amination reaction of carbonyl compounds. Despite developments of numerous new reductive amination methods in the past decades, this reaction generally requires non-atom-economic processes with harsh conditions and toxic transition-metal catalysts. Herein we report simple yet practical protocols using triflic acid as catalyst to efficiently promote direct reductive amination reactions of carbonyl compounds on a broad ranges of substrates. Applications of this new method to generate valuable heterocyclic frameworks and polyamines are also included.

Content

Thumbnail image of Reductive_Amination[9].pdf

Supplementary material

Thumbnail image of TOC.jpg
TOC
Thumbnail image of Reductive_Amination_SI[8].pdf
Reductive Amination SI[8]

Supplementary weblinks