A Dinuclear Copper Based Artificial Metalloenzyme for the Kinetic Resolution of Adrenalin

20 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Incorporation of a copper catalyst within carbonic anhydrase affords artificial metalloenzyme for the oxidation of catechols in aqueous solution at physiological pH. Optimization of the performance can be achieved either by chemical or genetic means. In addition, a model of enzyme/inhibitor is proposed and discussed.


artificial metalloenzyme
kinetic resolution


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.