A Mild and Simple Method for Making MIDA Boronates

03 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Existing methods for making MIDA boronates require harsh conditions and complex procedures to achieve dehydration. Here we disclose that a pre-dried form of MIDA, MIDA anhydride, acts as both a source of the MIDA ligand and an in situ desiccant to enable a mild and simple MIDA boronate synthesis procedure. This method expands the range of sensitive boronic acids that can be converted into their MIDA boronate counterparts. Further utilizing unique properties of MIDA boronates, we have developed a MIDA Boronate Maker Kit which enables the direct preparation and purification of MIDA boronates from boronic acids using only heating and centrifuge equipment that is widely available in labs that do not specialize in organic synthesis.

Keywords

boron
centrifuge
heterocycles
MIDA boronate
synthesis kit

Supplementary materials

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A Mild and Simple Method for Making MIDA Boronates
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