Continuous and Scalable Synthesis of a Porous Organic Cage by Twin Screw Extrusion (TSE)

01 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The continuous and scalable synthesis of a porous organic cage (CC3), obtained through a 10-component imine polycondensation between triformylbenzene and a vicinal diamine, was achieved using twin screw extrusion (TSE). Compared to both batch and flow syntheses, the use of TSE enabled the large scale synthesis of CC3 using minimal solvent and in short reaction times, with liquid-assisted grinding (LAG) also promoting window-to-window crystal packing to form a 3-D diamondoid pore network in the solid state. A new kinetically trapped [3+5] product was also observed alongside the formation of the targeted [4+6] cage species. Post-synthetic purification by Soxhlet extraction of the as-extruded ‘technical grade’ mixture of CC3 and [3+5] species rendered the material porous.


twin screw extrusion
porous organic cages

Supplementary materials

Egleston Cages by TSE ESI


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