Physical Chemistry

Polypeptides Folding: Rules for the Calculation of the Backbone Dihedral Angles φ starting from the Amino Acid Sequence

Authors

  • Michele Larocca Planetario Osservatorio Astronomico di Anzi-Basilicata, Anzi (PZ), Italy

Abstract

Protein folding is strictly related to the determination of the backbone dihedral angles and depends on the information contained in the amino acid sequence as well as on the hydrophobic effect. To date, the type of information embedded in the amino acid sequence has not yet been revealed. The present study deals with these problematics and aims to furnish a possible explanation of the information contained in the amino acid sequence, showing and reporting rules to calculate the backbone dihedral angles φ. The study is based on the development of mechanical forces once specific chemical interactions are established among the side chain of the residues in a polypeptide chain. It aims to furnish a theoretical approach to predict backbone dihedral angles which, in the future, may be applied to computational developments focused on the prediction of polypeptide structures.

Version notes

New Results

Content

Thumbnail image of Polypeptides Folding Rules for the Calculation of the Backbone Dihedral Angles phi starting from the Amino Acid Sequence.pdf

Supplementary material

Thumbnail image of _Supporting Information.pdf
Supporting Information Polypeptide Folding