Reaction of H2 with Mitochondria-Relevant Metabolites Using a Multifunctional Molecular Catalyst

18 March 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The Krebs cycle is the fuel/energy source for cellular activity, and therefore of paramount importance for oxygen-based life. The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH2, as well as C4-, C5-, and C6-polycarboxylic acids as energy-poor metabolites. These metabolites are bio-renewable resources that represent potential sustainable carbon feedstocks, provided that carbon–hydrogen bonds are restored to these molecules. In the present study, polycarboxylic acids of the Krebs cycle and other mitochondria-relevant metabolites are dehydrated and reduced to diols or triols upon reaction with H2, catalyzed by sterically confined iridium-bipyridyl complexes.

Keywords

iridium
hydrogenation catalyst
dehydration-induced
Catalysis
Krebs cycle metabolism
reduction
tetradentate chelation
Polycarboxylic Acids
polyols synthesis
phthalic acid
succinic acid conversion
citric acid cycle
Metal Complex
Molecular Catalysts

Supplementary materials

Title
Description
Actions
Title
irpcy2-retry4-final
Description
Actions
Title
ESI-Ir project ChemRxiv
Description
Actions

Supplementary weblinks

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