Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction

17 March 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. Combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multi-functionalized arene in a one-pot operation.

Keywords

Mizoroki–Heck reaction
alkenylation protocol
Palladium Catalysis
Nucleophilic Aromatic Substitutions
aryl electrophiles

Supplementary materials

Title
Description
Actions
Title
nitroHeck SI 20200316ChemRxiv
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Palladium-Catalyzed Mizoroki–Heck Reaction of Nitroarenes and Styrene Derivatives [opens in a new tab]
Toshimasa Okita, Kitty K. Asahara, Kei Muto, Junichiro Yamaguchi journal article
Organic Letters , Volume 22, Issue 8
Online publication date: Apr 02, 2020

Version History

Mar 17, 2020 Version 1

Metrics

3,994
1,058
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11988516.v1
D O I: 10.26434/chemrxiv.11988516.v1 [opens in a new tab]

Author’s competing interest statement

No competing financial interests have been declared.

Share