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Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction

17 March 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. Combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multi-functionalized arene in a one-pot operation.

Keywords

Mizoroki–Heck reaction
alkenylation protocol
Palladium Catalysis
Nucleophilic Aromatic Substitutions
aryl electrophiles

Supplementary materials

Title
Description
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Title
nitroHeck SI 20200316ChemRxiv
Description
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Now Published

Palladium-Catalyzed Mizoroki–Heck Reaction of Nitroarenes and Styrene Derivatives [opens in a new tab]
Toshimasa Okita, Kitty K. Asahara, Kei Muto, Junichiro Yamaguchi journal article
Organic Letters , Volume 22, Issue 8
Online publication date: Apr 02, 2020

Version History

Mar 17, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11988516.v1
D O I: 10.26434/chemrxiv.11988516.v1 [opens in a new tab]

Author’s competing interest statement

No competing financial interests have been declared.

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