Organic Chemistry

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides


We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

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Submitted version of manuscript


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2020 02 04 ESI Acevedo Rot DNA