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AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

07 February 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Keywords

rotaxanes
oligonucleotides
supramolecular
Mechanically Interlocked Architectures

Supplementary materials

Title
Description
Actions
Title
2020 02 04 ESI Acevedo Rot DNA
Description
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Now Published

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides [opens in a new tab]
Amanda Acevedo-Jake, Andrew T. Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel G. Singleton, Ali Tavassoli, Stephen M. Goldup journal article
Journal of the American Chemical Society , Volume 142, Issue 13
Online publication date: Mar 10, 2020

Version History

Feb 07, 2020 Version 1

Version Notes

Submitted version of manuscript

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11822289.v1
D O I: 10.26434/chemrxiv.11822289.v1 [opens in a new tab]

Funding

EPSRC (EP/L016621/1)
BBSRC (BB/J001694/2)
H2020 Marie Curie Individual Fellowship (798304, AAJ)
Royal Society Wolfson Fellowship (SMG)

Author’s competing interest statement

None

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