Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans

07 February 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.


drug delivery


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