Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans


In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The [email protected] biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.

Version notes

The corresponding authors are: Prof. Christian Doonan and Prof. Paolo Falcaro