Abstract
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CLpro cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.
Version notes
17/01/2020 Initial ChemRxiv upload - awaiting feedback from data suppliers
20/01/2020 Submission
Content

Supplementary material

TOC graphic
EMBOSS NEEDLE Alignments
Raw models
Refined Dimers
Refined monomers
Bat WH SARS protease
README
WH human 3CLproModel2 from3vb3 Minimised

Stoermer 2020 Wuhan CoV 3CLpro SI2301209
Stoermer 2020 Wuhan CoV 3CLpro230120
Stoermer 2020 Wuhan CoV 3CLpro SI2301209