Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Homology Models of Wuhan Coronavirus 3CLpro Protease

24 January 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CLpro cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.

Keywords

Wuhan coronavirus
protease
homology modeling
3CLpro

Supplementary materials

Title
Description
Actions
Title
TOC graphic
Description
Actions
Title
EMBOSS NEEDLE Alignments
Description
Actions
Title
Raw models
Description
Actions
Title
Refined Dimers
Description
Actions
Title
Refined monomers
Description
Actions
Title
Bat WH SARS protease
Description
Actions
Title
README
Description
Actions
Title
WH human 3CLproModel2 from3vb3 Minimised
Description
Actions
Title
Stoermer 2020 Wuhan CoV 3CLpro SI2301209
Description
Actions
Title
Stoermer 2020 Wuhan CoV 3CLpro230120
Description
Actions
Title
Stoermer 2020 Wuhan CoV 3CLpro SI2301209
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Jan 24, 2020 Version 1

Version Notes

17/01/2020 Initial ChemRxiv upload - awaiting feedback from data suppliers 20/01/2020 Submission

Metrics

24,541
10,195
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11637294.v1
D O I: 10.26434/chemrxiv.11637294.v1 [opens in a new tab]

Author’s competing interest statement

I declare that there are no conflicts of interest. This work is entirely derived from data in the public domain

Share