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Homology Models of Wuhan Coronavirus 3CLpro Protease

24 January 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CLpro cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.

Keywords

Wuhan coronavirus
protease
homology modeling
3CLpro

Supplementary materials

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Description
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TOC graphic
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EMBOSS NEEDLE Alignments
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Raw models
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Refined Dimers
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Refined monomers
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Bat WH SARS protease
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README
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WH human 3CLproModel2 from3vb3 Minimised
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Stoermer 2020 Wuhan CoV 3CLpro SI2301209
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Stoermer 2020 Wuhan CoV 3CLpro230120
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Stoermer 2020 Wuhan CoV 3CLpro SI2301209
Description
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Version History

Jan 24, 2020 Version 1

Version Notes

17/01/2020 Initial ChemRxiv upload - awaiting feedback from data suppliers 20/01/2020 Submission

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11637294.v1
D O I: 10.26434/chemrxiv.11637294.v1 [opens in a new tab]

Author’s competing interest statement

I declare that there are no conflicts of interest. This work is entirely derived from data in the public domain

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