Abstract
The December 2019 outbreak of pneumonia in Wuhan, Hubei Province of China was rapidly linked to a novel coronavirus 2019-nCoV. The rapid spread and severity of the virus has led the World Health Organization to declare it a Public Health Emergency of International Concern. We recently described the first homology models of the main 3CL protease from 2019-nCoV, and now present models of the other viral protease, the papain-like protease or PLpro. Whilst the overall viral genome is most closely associated with bat coronaviruses, no bat PLpro crystal structures are known. Wuhan 2019-nCoV PLpro is most closely related to a bat coronavirus PLpro (97% identity), then SARS (80 %) and MERS (29%) and the most promising models presented here are prepared from SARS crystal structure templates.
Version notes
v1.0 initial submission 04-02-2020
v1.1 Alternative title
Content

Supplementary material
Raw models
Refined models
WH PLpro
README
Stoermer 2020 Wuhan CoV PLpro SI
Stoermer 2020 Wuhan CoV PLpro

Stoermer 2020 Wuhan CoV PLpro SI