Robust Synthesis of NIR-Emissive P-Rhodamine Fluorophores

21 January 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


P-rhodamines were accessed by implementing a robust three step sequence consisting of (i) addition of m-metallated anilines to dichlorophosphine oxides, (ii) selective dibromination, and (iii) cyclization of the diaryllithium reagents derived from the dibromides to form the dihydroacridophosphine core of P-rhodamines. A modified route to produce non-symmetric P-rhodamines was additionally developed. A library of the prepared P-rhodamines provides first insight into dependence of fluorophore properties on the structure of P-rhodamines. A P-rhodamine with highest batochromic shifts and quantum yields in the class was identified.




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