Biological and Medicinal Chemistry

Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template


The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.


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Supplementary material

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draft 150120
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supp info