Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

13 January 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.


Late stage functionalization
carbene catalysis


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