Materials Science

Re-Programming Hydrogel Properties using a Fuel-driven Reaction Cycle

Abstract

Nature uses catalysis as an indispensable tool to control assembly and reaction cycles in vital non-equilibrium supramolecular processes. For instance, enzymatic methionine oxidation regulates actin (dis)assembly, and catalytic guanosine triphosphate hydrolysis is found in tubulin (dis)assembly. Here we present a completely artificial reaction cycle which is driven by a chemical fuel that is catalytically obtained from a ‘pre-fuel’. The reaction cycle controls the disassembly and re-assembly of a hydrogel, where the rate of pre-fuel turnover dictates the morphology as well as the mechanical properties. By adding additional fresh aliquots of fuel and removing waste, the hydrogels can be re-programmed time after time. Overall, we show how catalysis can control fuel generation to control reaction / assembly kinetics and materials properties in life-like non-equilibrium systems.

Version notes

v2: Fig. 1d and S3 have updated data after the reviewer comments, Fig. 3 now includes cycle number 12. The supporting information now included the full MATLAB code used to perform fitting.

Content

Thumbnail image of REV_SachCHO_20191221_Chemrxiv.pdf

Supplementary material

Thumbnail image of Video1_gel-sol-gel_vial.mp4
Video1 gel-sol-gel vial
Thumbnail image of Video2_microscopy.mp4
Video2 microscopy
Thumbnail image of REV_SI_SachCHO_20191221_GF_v2.pdf
REV SI SachCHO 20191221 GF v2