Total Synthesis of Putative Xestocyclamine A

08 January 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The first total synthesis of putative xestocyclamine A (-)-1 is reported, a compound taking center stage on the the pathway explaining the biosynthesis of a prominent family of polycyclic alkaloids (Baldwin-Whitehead pathway). The identity of the synthetic sample is unambiguous but the recorded spectral data deviate from those of xestocyclamine A reported in the literature.


Natural Product
Total Synthesis
macrocyclization strategy
Alkyne Metathesis
Suzuki reactions
Polycyclic Alkaloid


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